ThisrabbitIgGpolyclonalantibodywasgeneratedagainsttheGST-ADAM15-cytoplasmictailandisspecificforthecytoplasmicdomainofhumanADAM15.
TheADAM(ADisintegrinAndMetalloproteaseDomain)familyisauniquegroupofproteinsthathastheABIlitytocleaveorshedextracellularportionsoftransmembraneproteins.Inaddition,ADAMsareinvolvedincell-cellandcell-matrixinteractions(e.g.,fertilization,muscledevelopmentandneurogenesis).
ADAM15(Metargidin)isamembrane-anchoredmetalloproteinasethathasbeenimplicatedinpathologicalneovascularizationandprostatecancermetastasis.
FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.
PartofTheInvestigator"sAnnexeprogram.
| ProductType: | Antibody |
| AccessionID: | U41767 |
| Antigen: | GST-ADAM15cytoplasmicdomain |
| MolecularWeight: | ~110kDaunderreducingconditions |
| Isotype: | IgG |
| Clonality: | Polyclonal |
| Reactivity: | Human |
| Immunogen: | GST-cytocorrespondingtothecytoplasmicdomainofhumanADAM15 |
| SpeciesImmunized: | Rabbit |
| Epitope: | Cytoplasmicdomain |
| PurificationMethod: | Serum,notpurified |
| TestedApplications: | WB(1:500) |
| Storage: | -80C |
| Shipped: | Dryice |
| Antibody | SpeciesReactivity | Specificity |
| ADAM9 | Human | CytoplasmicDomain |
| ADAM9 | Mouse | CytoplasmicDomain |
| ADAM12 | Mouse | CytoplasmicDomain |
| ADAM15 | Human | CytoplasmicDomain |
| ADAM15 | Mouse | CytoplasmicDomain |
| ADAM15 | Human | ExtracellularDomain |
| ADAM15 | Mouse | DisintegrinDomain |
| ADAM17 | Mouse | CytoplasmicDomain |
| ADAM17 | Mouse | Prodomain |
| ADAM19 | Mouse | CytoplasmicDomain |
| ADAM28 | Mouse | CytoplasmicDomain |
| ADAM28 | Mouse | ExtracellularDomain |
| SNX9 | Mouse | CytoplasmicDomain |
- Krätzschmar,J.;Lum,L.;Blobel,C.P.Metargidin,amembrane-anchoredmetalloprotease-disintegrinproteinwithanRGDintegrinbindingsequence.J.Biol.Chem.1996,271,4593-4596.
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