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主营:cell lines, antibodies, small molecules, dyes ...
℡ 4000-520-616
℡ 4000-520-616
Kerafast/Anti-ADAM19 (mouse), Cytoplasmic Domain Antibody/EHS010/100uL
产品编号:EHS010
市  场 价:¥5980.00
场      地:美国(厂家直采)
产品分类: 抗体类>二抗>其他二抗>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$299.00
品      牌: Kerafast
公      司:Kerafast, Inc.
公司分类:
Kerafast/Anti-ADAM19 (mouse), Cytoplasmic Domain Antibody/EHS010/100uL
商品介绍

ThisrabbitIgGpolyclonalantibodywasgeneratedagainsttheGST-ADAM19-cytoplasmictailandisspecificforthecytoplasmicdomainofmouseADAM19.

TheADAM(ADisintegrinAndMetalloproteaseDomain)familyisauniquegroupofproteinsthathastheABIlitytocleaveorshedextracellularportionsoftransmembraneproteins.Inaddition,ADAMsareinvolvedincell-cellandcell-matrixinteractions(e.g.,fertilization,muscledevelopmentandneurogenesis).

ADAM19,alsoknownasmeltrinß,wasfirstidentifiedinmusclecellsandlaterexpressedinothertissues(e.g.heart,lungandbone).ThecatalyticactivityofADAM19hasbeenexploredbytheoverexpressionincellsandbypurifyingrecombinantlyexpressedsolubleformsoftheectodomainorthepro-andmetalloproteinasedomains.ADAM19hasanimportantroleduringcardiovascularmorphogenesis.

FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.

The InvestigatorPartofTheInvestigator"sAnnexeprogram.

Specifications
ProductType: Antibody
AccessionID: AF019887
Antigen: GST-ADAM19CytoplasmicDomain
MolecularWeight: ~120kDa
Isotype: IgG
Clonality: Polyclonal
Reactivity: Mouse
Immunogen: GST-fusionproteinwiththecytoplasmicdomainofmouseADAM19
SpeciesImmunized: Rabbit
Epitope: Cytoplasmicdomain
PurificationMethod: Serum,notpurified
TestedApplications: WB(1:500)
Storage: -80C
Shipped: Dryice
Research
AntibodySpeciesReactivitySpecificity
ADAM9HumanCytoplasmicDomain
ADAM9MouseCytoplasmicDomain
ADAM12MouseCytoplasmicDomain
ADAM15HumanCytoplasmicDomain
ADAM15MouseCytoplasmicDomain
ADAM15HumanExtracellularDomain
ADAM15MouseDisintegrinDomain
ADAM17MouseCytoplasmicDomain
ADAM17MouseProdomain
ADAM19MouseCytoplasmicDomain
ADAM28MouseCytoplasmicDomain
ADAM28MouseExtracellularDomain
SNX9MouseCytoplasmicDomain
Data

WesternBlotAnalysis

WesternblotanalysisofmouseprimaryosteoblastsprobedwithwholeADAM19antiserumata1:500dilution.

Adaptedfrom:InoueE,etal.J.Biol.Chem.1998,273,4180-4187.

Provider
FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.
References
  1. Inoue,D.;Reid,M.;Lum,L.;Krätzschmar,J.;Weskamp,G.;Myung,Y.M.;Baron,R.;Blobel,C.P.Cloningandinitialcharacterizationofmousemeltrinbetaandanalysisoftheexpressionoffourmetalloprotease-disintegrinsinbonecells.J.Biol.Chem.1998,273,4180-4187.
  2. Chesneau,V.;Becherer,J.D.;Zheng,Y.;Erdjument-Bromage,H.;Tempst,P.;Blobel,C.P.CatalyticpropertiesofADAM19.J.Biol.Chem.2003,278,22331-22340.
  3. Zhou,H.M.;Weskamp,G.;Chesneau,V.;Sahin,U.;Vortkamp,A.;Horiuchi,K.;Chiusaroli,R.;Hahn,R.;Wilkes,D.;Fisher,P.;Baron,R.;Manova,K.;Basson,C.T.;Hempstead,B.;Blobel,C.P.EssentialroleforADAM19incardiovascularmorphogenesis.Mol.Cell.Biol.2004,24,96-104.
  4. Kawaguchi,N.;Horiuchi,K.;Becherer,J.D.;Toyama,Y.;Besmer,P.;Blobel,C.P.DifferentADAMshavedistinctinfluencesonKitligandprocessing:phorbol-ester-stimulatedectodomainsheddingofKitl1byADAM17isreducedbyADAM19.J.Cell.Sci.2007,120,943-952.

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品牌介绍

Kerafast是位于波士顿的试剂公司,其主要任务是为全球科学界提供特有的实验室研究工具。其产品组合包括细胞系,抗体,小分子,染料等,其中许多在其他地方不可用。自2011年成立以来,全球超过160家机构的研究人员通过Kerafast在线平台提供了创新试剂,在这个平台上,材料可以快速访问,无需通过传统的材料转移协议流程。

在Kerafast,可通过MTA共享的材料,如抗体,细胞系,化合物,病毒载体,质粒等。随着文书工作,延误和成本不断上升,MTA交换过程正在成为学术实验室的沉重负担,因为Kerafast计划可以快速有效地进行补救。

 

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