ThisrabbitIgGpolyclonalantibodywasgeneratedagainsttheGST-ADAM19-cytoplasmictailandisspecificforthecytoplasmicdomainofmouseADAM19.
TheADAM(ADisintegrinAndMetalloproteaseDomain)familyisauniquegroupofproteinsthathastheABIlitytocleaveorshedextracellularportionsoftransmembraneproteins.Inaddition,ADAMsareinvolvedincell-cellandcell-matrixinteractions(e.g.,fertilization,muscledevelopmentandneurogenesis).
ADAM19,alsoknownasmeltrinß,wasfirstidentifiedinmusclecellsandlaterexpressedinothertissues(e.g.heart,lungandbone).ThecatalyticactivityofADAM19hasbeenexploredbytheoverexpressionincellsandbypurifyingrecombinantlyexpressedsolubleformsoftheectodomainorthepro-andmetalloproteinasedomains.ADAM19hasanimportantroleduringcardiovascularmorphogenesis.
FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.
PartofTheInvestigator"sAnnexeprogram.
| ProductType: | Antibody |
| AccessionID: | AF019887 |
| Antigen: | GST-ADAM19CytoplasmicDomain |
| MolecularWeight: | ~120kDa |
| Isotype: | IgG |
| Clonality: | Polyclonal |
| Reactivity: | Mouse |
| Immunogen: | GST-fusionproteinwiththecytoplasmicdomainofmouseADAM19 |
| SpeciesImmunized: | Rabbit |
| Epitope: | Cytoplasmicdomain |
| PurificationMethod: | Serum,notpurified |
| TestedApplications: | WB(1:500) |
| Storage: | -80C |
| Shipped: | Dryice |
| Antibody | SpeciesReactivity | Specificity |
| ADAM9 | Human | CytoplasmicDomain |
| ADAM9 | Mouse | CytoplasmicDomain |
| ADAM12 | Mouse | CytoplasmicDomain |
| ADAM15 | Human | CytoplasmicDomain |
| ADAM15 | Mouse | CytoplasmicDomain |
| ADAM15 | Human | ExtracellularDomain |
| ADAM15 | Mouse | DisintegrinDomain |
| ADAM17 | Mouse | CytoplasmicDomain |
| ADAM17 | Mouse | Prodomain |
| ADAM19 | Mouse | CytoplasmicDomain |
| ADAM28 | Mouse | CytoplasmicDomain |
| ADAM28 | Mouse | ExtracellularDomain |
| SNX9 | Mouse | CytoplasmicDomain |
WesternBlotAnalysis
WesternblotanalysisofmouseprimaryosteoblastsprobedwithwholeADAM19antiserumata1:500dilution.
Adaptedfrom:InoueE,etal.J.Biol.Chem.1998,273,4180-4187.
- Inoue,D.;Reid,M.;Lum,L.;Krätzschmar,J.;Weskamp,G.;Myung,Y.M.;Baron,R.;Blobel,C.P.Cloningandinitialcharacterizationofmousemeltrinbetaandanalysisoftheexpressionoffourmetalloprotease-disintegrinsinbonecells.J.Biol.Chem.1998,273,4180-4187.
- Chesneau,V.;Becherer,J.D.;Zheng,Y.;Erdjument-Bromage,H.;Tempst,P.;Blobel,C.P.CatalyticpropertiesofADAM19.J.Biol.Chem.2003,278,22331-22340.
- Zhou,H.M.;Weskamp,G.;Chesneau,V.;Sahin,U.;Vortkamp,A.;Horiuchi,K.;Chiusaroli,R.;Hahn,R.;Wilkes,D.;Fisher,P.;Baron,R.;Manova,K.;Basson,C.T.;Hempstead,B.;Blobel,C.P.EssentialroleforADAM19incardiovascularmorphogenesis.Mol.Cell.Biol.2004,24,96-104.
- Kawaguchi,N.;Horiuchi,K.;Becherer,J.D.;Toyama,Y.;Besmer,P.;Blobel,C.P.DifferentADAMshavedistinctinfluencesonKitligandprocessing:phorbol-ester-stimulatedectodomainsheddingofKitl1byADAM17isreducedbyADAM19.J.Cell.Sci.2007,120,943-952.
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