ThisrabbitIgGpolyclonalantibodywasgeneratedagainstthedisintegrin/cysteine-rich/EGFrepeatdomainofADAM15andrecognizesthedisintegrin/cysteine-rich/EGFrepeatdomainofmouseADAM15.
TheADAM(ADisintegrinAndMetalloproteaseDomain)familyisauniquegroupofproteinsthathastheABIlitytocleaveorshedextracellularportionsoftransmembraneproteins.Inaddition,ADAMsareinvolvedincell-cellandcell-matrixinteractions(e.g.,fertilization,muscledevelopmentandneurogenesis).
ADAM15(Metargidin)isamembrane-anchoredglycoproteinthathasbeenimplicatedinpathologicalneovascularizationandprostatecancermetastasis.
FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.
PartofTheInvestigator"sAnnexeprogram.
| ProductType: | Antibody |
| AccessionID: | AF006196 |
| Antigen: | ADAM15Disintegrin/Cysteine-rich/EGFrepeatdomain |
| MolecularWeight: | ~100kDa |
| Isotype: | IgG |
| Clonality: | Polyclonal |
| Reactivity: | Mouse |
| Immunogen: | Disintegrindomain,cysteine-richregionandanepidermalgrowthfactor(EGF)repeatfrommouseADAM15 |
| SpeciesImmunized: | Rabbit |
| Epitope: | Disintegrindomain,cysteine-richregionandanEGFrepeat |
| PurificationMethod: | Serum,notpurified |
| TestedApplications: | WB |
| Storage: | -80C |
| Shipped: | Dryice |
| Antibody | SpeciesReactivity | Specificity |
| ADAM9 | Human | CytoplasmicDomain |
| ADAM9 | Mouse | CytoplasmicDomain |
| ADAM12 | Mouse | CytoplasmicDomain |
| ADAM15 | Human | CytoplasmicDomain |
| ADAM15 | Mouse | CytoplasmicDomain |
| ADAM15 | Human | ExtracellularDomain |
| ADAM15 | Mouse | DisintegrinDomain |
| ADAM17 | Mouse | CytoplasmicDomain |
| ADAM17 | Mouse | Prodomain |
| ADAM19 | Mouse | CytoplasmicDomain |
| ADAM28 | Mouse | CytoplasmicDomain |
| ADAM28 | Mouse | ExtracellularDomain |
| SNX9 | Mouse | CytoplasmicDomain |
- Krätzschmar,J.;Lum,L.;Blobel,C.P.Metargidin,amembrane-anchoredmetalloprotease-disintegrinproteinwithanRGDintegrinbindingsequence.J.Biol.Chem.1996,271,4593-4596.
- LumL.;Reid,M.S.;Blobel,C.P.IntracellularmaturationofthemousemetalloproteasedisintegrinMDC15.J.BiolChem.1998,273,26236-26247.
- Horiuchi,K.;Weskamp,G.;Lum,L.;Hammes,H.P.;Cai,H.;Brodie,T.A.;Ludwig,T.;Chiusaroli,R.;Baron,R.;Preissner,K.T.;Manova,K.;Blobel,C.P.PotentialroleforADAM15inpathologicalneovascularizationinmice.Mol.Cell.Biol.2003,23,5614-5624.
- Maretzky,T.;Yang,G.;Ouerfelli,O.;Overall,C.M.;Worpenberg,S.;Hassiepen,U.;Eder,J.;Blobel,C.P.Characterizationofthecatalyticactivityofthemembrane-anchoredmetalloproteinaseADAM15incell-basedassays.BiochemJ.2009,420,105-113.
- Maretzky,T.;LeGall,S.M.;Worpenberg-Pietruk,S.;Eder,J.;Overall,C.M.;Huang,X.Y.;Poghosyan,Z.;Edwards,D.R.;Blobel,C.P.Srcstimulatesfibroblastgrowthfactorreceptor-2sheddingbyanADAM15splicevariantlinkedtobreastcancer.CancerRes.2009,69,4573-4576.
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