Kerafast/Anti-ADAM17 (mouse), Cytoplasmic Domain Antibody/EHS008/100uL,Kerafast,,Kerafast,Kerafast Inc,Kerafast批发，产品货源 Kerafast Inc现货代理,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Kerafast/Anti-ADAM17 (mouse), Cytoplasmic Domain Antibody/EHS008/100uL

产品编号：EHS008

市场价：¥5980.00

场地：美国(厂家直采)

产品分类：抗体类>二抗>其他二抗>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$299.00

品牌： Kerafast

公司：Kerafast, Inc.

公司分类：

商品介绍

ThisrabbitIgGpolyclonalantibodywasgeneratedagainsttheGST-ADAM17-cytoplasmictailandisspecificforthecytoplasmicdomainofmouseADAM17.

TheADAM(ADisintegrinAndMetalloproteaseDomain)familyisauniquegroupofproteinsthathastheABIlitytocleaveorshedextracellularportionsoftransmembraneproteins.Inaddition,ADAMsareinvolvedincell-cellandcell-matrixinteractions(e.g.,fertilization,muscledevelopmentandneurogenesis).

ADAM17(alsoreferredtoasTumorNecrosisFactorConvertase,TACE)isinvolvedintheprocessingoftumornecrosisfactoralpha(TNF-a)atthesurfaceofthecell,andisalsorequiredforsheddingseveralligandsoftheepidermalgrowthfactorreceptorandmanyothermembraneproteins.

FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.

The Investigator PartofTheInvestigator"sAnnexeprogram.

Specifications

ProductType:	Antibody
Antigen:	GST-ADAM17CytoplasmcDomain
MolecularWeight:	~100kDa(matureform),~120kDa(pro-form)
Isotype:	IgG
Clonality:	Polyclonal
Reactivity:	Mouse
Immunogen:	GST-cytocorrespondingtothecytoplasmicdomainofmouseADAM17
SpeciesImmunized:	Rabbit
Epitope:	Cytoplasmicdomain
PurificationMethod:	Serum,notpurified
TestedApplications:	WB(1:1000)
Storage:	-80C
Shipped:	Dryice

ADAM17(mouse),CytoplasmicDomainAntibody

AntigenName:	GST-ADAM17CytoplasmcDomain
MolecularWeight:	~100kDa(matureform),~120kDa(pro-form)
ImmunoglobulinIsotype:	IgG
Clonality:	Polyclonal
SpeciesReactivity:	Mouse
TypeofImmunogen:	GST-cytocorrespondingtothecytoplasmicdomainofmouseADAM17
Epitope:	Cytoplasmicdomain
SpeciesImmunized:	Rabbit
PurificationMethod:	Serum,notpurified
TestedApplications:	WB(1:1000)
StorageTemperature:	-80C
Shipped:	Dryice

FindthebestADAMAntibodyforyourresearch:

Antibody	SpeciesReactivity	Specificity
ADAM9	Human	CytoplasmicDomain
ADAM9	Mouse	CytoplasmicDomain
ADAM12	Mouse	CytoplasmicDomain
ADAM15	Human	CytoplasmicDomain
ADAM15	Mouse	CytoplasmicDomain
ADAM15	Human	ExtracellularDomain
ADAM15	Mouse	DisintegrinDomain
ADAM17	Mouse	CytoplasmicDomain
ADAM17	Mouse	Prodomain
ADAM19	Mouse	CytoplasmicDomain
ADAM28	Mouse	CytoplasmicDomain
ADAM28	Mouse	ExtracellularDomain
SNX9	Mouse	CytoplasmicDomain

Comments

Celllysisbuffermustcontain5mM1,10PhenanthrolinetopreventautodegradationofthematureformofADAM17,whichisnotpreventedbyEDTAortypicalproteaseinhibitorcocktails(Schlöndorffetal.,BiochemJ.2000,347,131-138).

Data

WesternBlotAnalysis

Antibodies:prodomainfusedtoGST(α-PRO),GST-fusionproteincontainingthecyotplasmicdomain(α-CYTO).

Adaptedfrom:SchlöndorffJ,etal.JBiochemJ.2000,347,131-138.

References

Schlöndorff,J.;Becherer,J.D.;Blobel,C.P.Intracellularmaturationandlocalizationofthetumournecrosisfactoralphaconvertase(TACE).BiochemJ.2000,347,131-138.
Zheng,Y.;Schlondorff,J.;Blobel,C.P.Evidenceforregulationofthetumornecrosisfactoralpha-convertase(TACE)byprotein-tyrosinephosphatasePTPH1.J.Biol.Chem.2002,277,42463-42470.
Horiuchi,K.;KimuraT.;MiyamotoT.;TakaishiH.;OkadaY.;Toyama,Y.,Blobel,C.P.Cuttingedge:TNF-alpha-convertingenzyme(TACE/ADAM17)inactivationinmousemyeloidcellspreventslethalityfromendotoxinshock.J.Immunol.2007,179,2686-2689.
LeGall,S.M.,Maretzky,T.,Issuree,P.D.,Niu,X.D.;Reiss,K.,Saftig,P.,Khokha,R.,Lundell,D.,Blobel,C.P.ADAM17isregulatedbyarapidandreversIBLemechanismthatcontrolsaccesstoitscatalyticsite.J.Cell.Sci.2010,123,3913-3922.
Maretzky,T.,Evers,A.,Zhou,W.,Swendeman,S.L.,Wong,P.M.,Rafii,S.,Reiss,K.,BlobelC.P.Migrationofgrowthfactor-stimulatedepithelialandendothelialcellsdependsonEGFRtransactivationbyADAM17.Nat.Commun.2011,2,1-25.

Ifyoupublishresearchwiththisproduct,pleaseletusknowsowecanciteyourpaper.

Research

Antibody	SpeciesReactivity	Specificity
ADAM9	Human	CytoplasmicDomain
ADAM9	Mouse	CytoplasmicDomain
ADAM12	Mouse	CytoplasmicDomain
ADAM15	Human	CytoplasmicDomain
ADAM15	Mouse	CytoplasmicDomain
ADAM15	Human	ExtracellularDomain
ADAM15	Mouse	DisintegrinDomain
ADAM17	Mouse	CytoplasmicDomain
ADAM17	Mouse	Prodomain
ADAM19	Mouse	CytoplasmicDomain
ADAM28	Mouse	CytoplasmicDomain
ADAM28	Mouse	ExtracellularDomain
SNX9	Mouse	CytoplasmicDomain

Data

WesternBlotAnalysis

Antibodiesagainst:pro-domainfusedtoGST(α-PRO),cytoplasmicdomainfusedtoGST(α-CYTO).

Adaptedfrom:SchlöndorffJ,etal.JBiochemJ.2000,347,131-138.

Provider

FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.

Comments

References

Schlöndorff,J.;Becherer,J.D.;Blobel,C.P.Intracellularmaturationandlocalizationofthetumournecrosisfactoralphaconvertase(TACE).BiochemJ.2000,347,131-138.
Zheng,Y.;Schlondorff,J.;Blobel,C.P.Evidenceforregulationofthetumornecrosisfactoralpha-convertase(TACE)byprotein-tyrosinephosphatasePTPH1.J.Biol.Chem.2002,277,42463-42470.
Horiuchi,K.;KimuraT.;MiyamotoT.;TakaishiH.;OkadaY.;Toyama,Y.,Blobel,C.P.Cuttingedge:TNF-alpha-convertingenzyme(TACE/ADAM17)inactivationinmousemyeloidcellspreventslethalityfromendotoxinshock.J.Immunol.2007,179,2686-2689.
LeGall,S.M.,Maretzky,T.,Issuree,P.D.,Niu,X.D.;Reiss,K.,Saftig,P.,Khokha,R.,Lundell,D.,Blobel,C.P.ADAM17isregulatedbyarapidandreversiblemechanismthatcontrolsaccesstoitscatalyticsite.J.Cell.Sci.2010,123,3913-3922.
Maretzky,T.,Evers,A.,Zhou,W.,Swendeman,S.L.,Wong,P.M.,Rafii,S.,Reiss,K.,BlobelC.P.Migrationofgrowthfactor-stimulatedepithelialandendothelialcellsdependsonEGFRtransactivationbyADAM17.Nat.Commun.2011,2,1-25.
McIlwainDR,LangPA,MaretzkyT,HamadaK,OhishiK,ManeySK,BergerT,MurthyA,DuncanG,XuHC,LangKS,HäussingerD,WakehamA,Itie-YoutenA,KhokhaR,OhashiPS,BlobelCP,MakTW.iRhom2regulationofTACEcontrolsTNF-mediatedprotectionagainstListeriaandresponsestoLPS.Science.2012Jan13;335(6065):229-32.

Ifyoupublishresearchwiththisproduct,pleaseletusknowsowecanciteyourpaper.

品牌介绍

Kerafast是位于波士顿的试剂公司，其主要任务是为全球科学界提供特有的实验室研究工具。其产品组合包括细胞系，抗体，小分子，染料等，其中许多在其他地方不可用。自2011年成立以来，全球超过160家机构的研究人员通过Kerafast在线平台提供了创新试剂，在这个平台上，材料可以快速访问，无需通过传统的材料转移协议流程。

在Kerafast，可通过MTA共享的材料，如抗体，细胞系，化合物，病毒载体，质粒等。随着文书工作，延误和成本不断上升，MTA交换过程正在成为学术实验室的沉重负担，因为Kerafast计划可以快速有效地进行补救。

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