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Kerafast/Anti-ADAM17 (mouse), Pro Domain Antibody/EHS009/100uL

Kerafast/Anti-ADAM17 (mouse), Pro Domain Antibody/EHS009/100uL
  • Kerafast/Anti-ADAM17 (mouse), Pro Domain Antibody/EHS009/100uL
商品介绍

ThisrabbitIgGpolyclonalantibodywasgeneratedagainstthepro-domainofmouseADAM17andisspecificforthepro-domainofmouseADAM17.

TheADAM(ADisintegrinAndMetalloproteaseDomain)familyisauniquegroupofproteinsthathastheABIlitytocleaveorshedextracellularportionsoftransmembraneproteins.Inaddition,ADAMsareinvolvedincell-cellandcell-matrixinteractions(e.g.,fertilization,muscledevelopmentandneurogenesis).

ADAM17(alsoreferredtoasTumorNecrosisFactorConvertase,TACE)isinvolvedintheprocessingoftumornecrosisfactoralpha(TNF-a)atthesurfaceofthecell,andisalsorequiredforsheddingseveralligandsoftheepidermalgrowthfactorreceptorandmanyothermembraneproteins.TheprodomainofcatalyticallyactiveADAMsisthoughttoactasaninhibitoroftheproteaseviaacysteine-switchmechanism.ProdomainremovalisthereforethoughttobeaprerequisiteforADAM17proteaseactivity.

FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.

The InvestigatorPartofTheInvestigator"sAnnexeprogram.

Specifications
ProductType: Antibody
Antigen: ADAM17Pro-Domain
MolecularWeight: ~120kDa
Isotype: IgG
Clonality: Polyclonal
Reactivity: Mouse
Immunogen: Pro-domainofmouseADAM17
SpeciesImmunized: Rabbit
Epitope: Pro-domain
PurificationMethod: Serum,notpurified
TestedApplications: WB(1:250)
Storage: -80C
Shipped: Dryice
Research
AntibodySpeciesReactivitySpecificity
ADAM9HumanCytoplasmicDomain
ADAM9MouseCytoplasmicDomain
ADAM12MouseCytoplasmicDomain
ADAM15HumanCytoplasmicDomain
ADAM15MouseCytoplasmicDomain
ADAM15HumanExtracellularDomain
ADAM15MouseDisintegrinDomain
ADAM17MouseCytoplasmicDomain
ADAM17MouseProdomain
ADAM19MouseCytoplasmicDomain
ADAM28MouseCytoplasmicDomain
ADAM28MouseExtracellularDomain
SNX9MouseCytoplasmicDomain
Data

WesternBlotAnalysis

Antibodiesagainst:pro-domainfusedtoGST(α-PRO),cytoplasmicdomainfusedtoGST(α-CYTO).

Adaptedfrom:SchlöndorffJ,etal.JBiochemJ.2000,347,131-138.

Provider
FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.
References
  1. Schlöndorff,J.;Becherer,J.D.;Blobel,C.P.Intracellularmaturationandlocalizationofthetumournecrosisfactoralphaconvertase(TACE).BiochemJ.2000,347,131-138.
  2. McIlwainDR,LangPA,MaretzkyT,HamadaK,OhishiK,ManeySK,BergerT,MurthyA,DuncanG,XuHC,LangKS,HäussingerD,WakehamA,Itie-YoutenA,KhokhaR,OhashiPS,BlobelCP,MakTW.iRhom2regulationofTACEcontrolsTNF-mediatedprotectionagainstListeriaandresponsestoLPS.Science.2012Jan13;335(6065):229-32.

Ifyoupublishresearchwiththisproduct,pleaseletusknowsowecanciteyourpaper.

品牌介绍

Kerafast是位于波士顿的试剂公司,其主要任务是为全球科学界提供特有的实验室研究工具。其产品组合包括细胞系,抗体,小分子,染料等,其中许多在其他地方不可用。自2011年成立以来,全球超过160家机构的研究人员通过Kerafast在线平台提供了创新试剂,在这个平台上,材料可以快速访问,无需通过传统的材料转移协议流程。

在Kerafast,可通过MTA共享的材料,如抗体,细胞系,化合物,病毒载体,质粒等。随着文书工作,延误和成本不断上升,MTA交换过程正在成为学术实验室的沉重负担,因为Kerafast计划可以快速有效地进行补救。

 

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