ThisrabbitIgGpolyclonalantibodywasgeneratedagainstthepro-domainofmouseADAM17andisspecificforthepro-domainofmouseADAM17.
TheADAM(ADisintegrinAndMetalloproteaseDomain)familyisauniquegroupofproteinsthathastheABIlitytocleaveorshedextracellularportionsoftransmembraneproteins.Inaddition,ADAMsareinvolvedincell-cellandcell-matrixinteractions(e.g.,fertilization,muscledevelopmentandneurogenesis).
ADAM17(alsoreferredtoasTumorNecrosisFactorConvertase,TACE)isinvolvedintheprocessingoftumornecrosisfactoralpha(TNF-a)atthesurfaceofthecell,andisalsorequiredforsheddingseveralligandsoftheepidermalgrowthfactorreceptorandmanyothermembraneproteins.TheprodomainofcatalyticallyactiveADAMsisthoughttoactasaninhibitoroftheproteaseviaacysteine-switchmechanism.ProdomainremovalisthereforethoughttobeaprerequisiteforADAM17proteaseactivity.
FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.
PartofTheInvestigator"sAnnexeprogram.
| ProductType: | Antibody |
| Antigen: | ADAM17Pro-Domain |
| MolecularWeight: | ~120kDa |
| Isotype: | IgG |
| Clonality: | Polyclonal |
| Reactivity: | Mouse |
| Immunogen: | Pro-domainofmouseADAM17 |
| SpeciesImmunized: | Rabbit |
| Epitope: | Pro-domain |
| PurificationMethod: | Serum,notpurified |
| TestedApplications: | WB(1:250) |
| Storage: | -80C |
| Shipped: | Dryice |
| Antibody | SpeciesReactivity | Specificity |
| ADAM9 | Human | CytoplasmicDomain |
| ADAM9 | Mouse | CytoplasmicDomain |
| ADAM12 | Mouse | CytoplasmicDomain |
| ADAM15 | Human | CytoplasmicDomain |
| ADAM15 | Mouse | CytoplasmicDomain |
| ADAM15 | Human | ExtracellularDomain |
| ADAM15 | Mouse | DisintegrinDomain |
| ADAM17 | Mouse | CytoplasmicDomain |
| ADAM17 | Mouse | Prodomain |
| ADAM19 | Mouse | CytoplasmicDomain |
| ADAM28 | Mouse | CytoplasmicDomain |
| ADAM28 | Mouse | ExtracellularDomain |
| SNX9 | Mouse | CytoplasmicDomain |
WesternBlotAnalysis
Antibodiesagainst:pro-domainfusedtoGST(α-PRO),cytoplasmicdomainfusedtoGST(α-CYTO).
Adaptedfrom:SchlöndorffJ,etal.JBiochemJ.2000,347,131-138.
- Schlöndorff,J.;Becherer,J.D.;Blobel,C.P.Intracellularmaturationandlocalizationofthetumournecrosisfactoralphaconvertase(TACE).BiochemJ.2000,347,131-138.
- McIlwainDR,LangPA,MaretzkyT,HamadaK,OhishiK,ManeySK,BergerT,MurthyA,DuncanG,XuHC,LangKS,HäussingerD,WakehamA,Itie-YoutenA,KhokhaR,OhashiPS,BlobelCP,MakTW.iRhom2regulationofTACEcontrolsTNF-mediatedprotectionagainstListeriaandresponsestoLPS.Science.2012Jan13;335(6065):229-32.
Ifyoupublishresearchwiththisproduct,pleaseletusknowsowecanciteyourpaper.
Kerafast是位于波士顿的试剂公司，其主要任务是为全球科学界提供特有的实验室研究工具。其产品组合包括细胞系，抗体，小分子，染料等，其中许多在其他地方不可用。自2011年成立以来，全球超过160家机构的研究人员通过Kerafast在线平台提供了创新试剂，在这个平台上，材料可以快速访问，无需通过传统的材料转移协议流程。
在Kerafast，可通过MTA共享的材料，如抗体，细胞系，化合物，病毒载体，质粒等。随着文书工作，延误和成本不断上升，MTA交换过程正在成为学术实验室的沉重负担，因为Kerafast计划可以快速有效地进行补救。
![Kerafast/Anti-Acetylated Mannan [CCRC-M169, 2C2.D8.E5] Antibody (supernatant)/EGA144/5mL (supernatant)](images/kerafast/2909.jpg)
![Kerafast/Anti-Actin-1 [mAb45a] Antibody/EGA002/100ug](images/kerafast/1477.jpg)
![Kerafast/Anti-Acetylated Glucomannan [CCRC-M170] Antibody/EGA828/Supernatant, 5mL](images/kerafast/2204.jpg)
本网站将在规定时间内给予删除等相关处理。
